As each year, the conference will be held on the Caltech Pasadena Campus:
360 S Wilson Ave Pasadena CA
The conference itself, as well as the advanced track tutorials, will be held in the Beckman institute. Other tutorials take place in the Moore building, while Powell-Booth will house the sprints (after the conference) and the birds-of-a-feather sessions.
Caltech also has an online campus map available.
Accommodations: We have negotiated a group rate at a nearby Marriot Hotel (starting at $154/night). They've provided a web site for the event, so you can book a room here. You will have to book by July 19 to get the group rate. There's a map showing the relative location here.
Some helpful links: